UPSTREAM BIO INC

$UPB
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Smart money positioned

8 of the Top-200 alpha managers hold $UPB as of the latest 13F snapshot.

13F holders
8
Insider buys · 90d
0
Congress · 90d
0

Smart Money · top-200 alpha cohort

8 holders · Q1 2026

$UPB is held by 8 managers from the Top-Performer cohort as of Q1 2026. Position weights range from 0.00% to 6.30%, with an average of 1.07% of portfolio. Largest holder: Enavate Sciences GP, LLC at 6.30%. A weekly Smart-Money commentary for this ticker has not been generated yet this batch — the table below shows the full cohort positioning.

01
Enavate Sciences GP, LLC
6.30% ↓ 6.9pp
α +74.0pts
02
Knightsbridge Asset Management, LLC
0.06% held
α +24.2pts
03
Diadema Partners LP
0.03% held
α +13.2pts
04
ADAR1 Capital Management, LLC
0.02% held
α +74.0pts
05
Nisa Investment Advisors, LLC
0.00% held
α +16.6pts

Smart Money shows holdings from our Top-Performer cohort — the 200 highest-alpha manager_13f funds in our universe. Position weight (current quarter) and QoQ delta versus prior quarter. α is the manager's annual alpha vs benchmark.

Institutional holders

Top 8 of 8 · Source: 13F-HR
01
Enavate Sciences GP, LLC
4.93% of portfolio
2,459,703 sh
02
Vanguard Group Inc.
—
2,388,439 sh
03
State Street
—
766,323 sh
04
Renaissance Technologies
—
131,300 sh
05
Two Sigma
—
42,325 sh
06
Citigroup Inc.
—
40,339 sh
07
WINTON GROUP Ltd
—
19,800 sh
08
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC
—
588 sh

Insider activity · last 90 days

26 transactions · 11 filers
16 Jun 2026
Sutherland Everett Rand —
▼ SOLD
2,095
$6.10
S
16 Jun 2026
Ambrose Allison —
▼ SOLD
477
$6.10
S
16 Jun 2026
Gray Michael —
▼ SOLD
853
$6.10
S
16 Jun 2026
Houghton Adam —
▼ SOLD
700
$6.10
S
16 Jun 2026
Deykin Aaron —
▼ SOLD
895
$6.10
S
09 Jun 2026
Renaud Ronald C JR —
· GRANT
17,096
—
A
09 Jun 2026
Beckman Daniella —
· GRANT
17,096
—
A
09 Jun 2026
Ratcliffe Liam —
· GRANT
17,096
—
A
09 Jun 2026
Chimovits Erez —
· GRANT
17,096
—
A
09 Jun 2026
Ruddy Marcella K. —
· GRANT
17,096
—
A
09 Jun 2026
Fleming Harold Edward —
· GRANT
17,096
—
A
16 Mar 2026
Deykin Aaron —
▼ SOLD
894
$9.28
S

Transaction codes: P open-market purchase · S sale · M option exercise · A grant · F tax-withhold sale. Insider names link to each individual's expert page.

Congress trades · last 90 days

No Congress trades

No STOCK Act filings reference $UPB in the recent window.

Convergence · $UPB

Pattern cards reflect public SEC EDGAR and Congressional filing data only. Detection uses filing dates; trade execution dates may differ. Past convergence patterns do not predict future returns. Nothing here is investment advice.

Source data: SEC EDGAR · 13F-HR · Form 4 · U.S. House Clerk PTR (disclosures-clerk.house.gov) · Senate eFD (senate.gov) · Last refreshed 17:08 UTC.