UPSTREAM BIO INC

$UPB
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Smart money positioned

8 of the Top-200 alpha managers hold $UPB as of the latest 13F snapshot.

13F holders
137
Insider buys · 90d
0
Congress · 90d
0

Smart Money · top-200 alpha cohort

8 holders · Q1 2026

$UPB is held by 8 managers from the Top-Performer cohort as of Q1 2026. Position weights range from 0.00% to 6.30%, with an average of 1.07% of portfolio. Largest holder: Enavate Sciences GP, LLC at 6.30%. A weekly Smart-Money commentary for this ticker has not been generated yet this batch — the table below shows the full cohort positioning.

01
Enavate Sciences GP, LLC
6.30% ↓ 6.9pp
α +74.0pts
02
Knightsbridge Asset Management, LLC
0.06% held
α +24.2pts
03
Diadema Partners LP
0.03% held
α +13.2pts
04
ADAR1 Capital Management, LLC
0.02% held
α +74.0pts
05
Nisa Investment Advisors, LLC
0.00% held
α +16.6pts

Smart Money shows holdings from our Top-Performer cohort — the 200 highest-alpha manager_13f funds in our universe. Position weight (current quarter) and QoQ delta versus prior quarter. α is the manager's annual alpha vs benchmark.

Institutional holders

Top 10 of 137 · Source: 13F-HR
01
Sculptor Capital LP
1.02% of portfolio
5,693,589 sh
02
ProShare Advisors LLC
0.01% of portfolio
2,882,647 sh
03
Foundry Financial Group, Inc.
3.79% of portfolio
2,724,868 sh
04
ADAR1 Capital Management, LLC
6.30% of portfolio
2,459,703 sh
05
Enavate Sciences GP, LLC
14.13% of portfolio
2,459,703 sh
06
State Street
—
1,319,226 sh
07
VR Adviser, LLC
1.39% of portfolio
1,169,298 sh
08
Artemis Wealth Advisors, LLC
0.17% of portfolio
1,000,631 sh
09
Nomura Asset Management Co. Ltd.
0.01% of portfolio
979,758 sh
10
Samsara BioCapital, LLC
2.37% of portfolio
962,154 sh
See all 137 13F holders · Pro →

Insider activity · last 90 days

No insider activity

No Form 4 filings on record for $UPB in the recent window.

Congress trades · last 90 days

No Congress trades

No STOCK Act filings reference $UPB in the recent window.

Source data: SEC EDGAR · 13F-HR · Form 4 · U.S. House Clerk PTR (disclosures-clerk.house.gov) · Senate eFD (senate.gov) · Last refreshed 06:52 UTC.